Mitochondrial disease includes a group of neuromuscular diseases caused by damage to intracellular structures that produce energy, the mitochondria; disease symptoms usually involve muscle contractions that are weak or spontaneous. There is no specific treatment for mitochondrial diseases
The primary mitochondrial function in animal cells is the production of energy in the form of ATP, and the regulation of cellular metabolism. The reactions that are involved in the production of ATP are collectively known as the Citric Acid Cycle or Krebs Cycle.
M.W. Gray, in Encyclopedia of Genetics, 2001. Structure. The mitochondrion has two bounding membranes, outer and inner, which are structurally and functionally distinct. One major difference is their permeability properties: the outer membrane permits free passage of most molecules of molecular weight less than about 10 000 daltons, whereas the inner membrane forms an effective barrier to even
Mitochondria have a distinctive oblong or oval shape and are bounded by a double membrane. The inner membrane is folded creating structures known as cristae.. Mitochondria are found in both animal and plant cells.They are found in all body cell types, except for mature red blood cells.The number of mitochondria within a cell varies depending on the type and function of the cell.
Mitochondrial damage and hepatic iron accumulation contribute to the hepatocarcinogenesis in chronic hepatitis C. • HCV causes mitochondrial injury through direct interaction with mitochondria and/or mitochondrial calcium regulation. • Hepcidin plays a critical role in hepatic iron accumulation in chronic hepatitis C. •
Oxidative stress leads to severe health complications by producing excessive free radicals with a goal to complete demolition work to the structure of cells and inhibit their function. Mitochondria are primary targets of oxidative damage because they are the main sites of cellular respiration which free radicals may be generated in high amounts